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With Spurs and West Ham enjoying a Double Gameweek, the striker is the chief candidate for the captaincy.
Manchester United have a tough fixture away to Everton while Manchester City probably have the easiest of the lot as they face Watford at home. Meanwhile, Chelsea and Arsenal go head-to-head as Liverpool travel to Burnley.
Here are a few pointers to guide you ahead of Gameweek 22.
Mohamed Salah was the captain pick last week and he came up with the goods yet again with a match-winning brace that earned him 14 points, doubling to 28.
This time around, Kane is the obvious choice although a slight illness has thrown a spanner in the works. With comfortable fixtures away to Swansea City and at home to West Ham lined up for the striker in a DGW for Spurs, plenty will be considering using their Triple Captain chip on him as well.
However, he is no longer a certain starter for the game against Swansea at least so we’ll have to wait on the latest news. If it turns out that he is good to play, then you can’t afford not to give him the armband. If not, there are a few alternatives below.
MOHAMED SALAH (10.1m) can never be left out of the conversation when picking your captain. He’s now delivered a remarkable 10 times in his last 11 GWs. The only question is; will he finally be afforded a rest?
HEUNG-MIN SON (8.0m) has started the last six games and has reignited Spurs, scoring four goals and providing four assists in that time. If he plays both games over the DGW, he could be in for another double-figure score.
NICOLAS OTAMENDI (6.4m) has picked up four clean sheets in five games and we already know he’s got an eye for goal, scoring four times already this season. It’s about that time again for him to bag another as he faces Watford at home.
ADRIAN | WEST HAM UNITED | 4.3M
After three clean sheets on the bounce, West Ham have conceded six in their last two outings. However, it’s a good bet that David Moyes will get his team to manage a shut out against West Brom who have been woeful going forward. With the DGW as well, even if Adrian doesn’t keep a clean sheet against Spurs, he’s likely to be peppered with shots, which could lead to a couple of save points.
MARCUS RASHFORD | MANCHESTER UNITED | 7.6M
It’s unclear how long Romelu Lukaku will be sidelined for owing to his injury against Southampton but the Belgian looks set to miss the next couple of games at least. That paves the way for Marcus Rashford to start as the main striker. It’s not an ideal scenario and United are far from their best, but the young Red did step up to the plate and deliver last season when Zlatan Ibrahimovic was ruled out with a knee injury.
EDEN HAZARD| CHELSEA | 10.8M
After failing to start on Saturday, Eden Hazard has now managed just one assist in the last six GWs. At his price, that’s simply unacceptable. With so many far cheaper midfielders doing better, including his team-mate Willian, it doesn’t make sense to keep hold of the Belgian.
ASHLEY YOUNG | MANCHESTER UNITED | 5.1M
Following an off the ball incident with Dusan Tadic where Ashley Young appeared to elbow the Southampton midfielder, the defender has been charged by the Football Association. If the charge goes uncontested, the full-back will miss the next three games.
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Alexis Sanchez scored again but his late goal was not enough for all three points against West Brom as Arsenal had to settle for a 1-1 draw.
The Chile forward is out of contract in the summer and with the transfer window set to open tomorrow, the speculation regarding his future is sure to intensify.
Here, Press Association Sport takes a look at how Sanchez performed at The Hawthorns.
Sanchez saw little of the ball during the first half, causing him to drop deep.
But in doing so it further isolated Alexandre Lacazette and often Sanchez would surrender possession, failing to find a team-mate with a simple pass.
He linked up well with Lacazette in and around the West Brom penalty area on one occasion in the first half but it ultimately led to nothing.
The same two players combined just after the hour mark but Lacazette could only poke Sanchez’s clever little pass narrowly wide.
It took until the 50th minute for Sanchez to have a shot at goal.
The 29-year-old stood menacingly over a free-kick just outside the penalty area in a central position but his effort struck the West Brom defensive wall.
Twenty minutes later he saw a fiercely-struck left-foot shot from inside the box blocked at close quarters by Ahmed Hegazi.
Having had a sighter, Sanchez scored with a free-kick from a near identical position with seven minutes remaining, although his shot did take a telling deflection en route to the net.
Being on the periphery of the action does not suit Sanchez and at times the Chile international did look miserable and frustrated.
However, you could not say it affected his effort. Sanchez did chase and put West Brom defenders and midfielders under pressure.
He gestured at team-mates on more than one occasion after feeling they could have offered him a better option but this could not really be interpreted as petulance.
A quiet afternoon for Sanchez, but then Arsenal as a team were not really at the races.
When things are not going according to plan Sanchez takes it upon himself to try to make something happen and ends up trying to do too much.
He celebrated his goal with some gusto, however, along with the rest of his team-mates, which was not the case at Crystal Palace a few days ago.
Jay Rodriguez’s last-minute penalty earned struggling West Brom a deserved point against uninspiring Arsenal.
The striker netted after Calum Chambers handled in the area to clinch a 1-1 draw just as it looked like Alexis Sanchez had given the Gunners victory.
The forward’s deflected free-kick put Arsenal ahead with seven minutes left in boss Arsene Wenger’s record-breaking 811th Premier League game in charge.
Ahmed Hegazi. The Egypt international has impressed during his short time in the Premier League and he was solid again at the back for West Brom.
Moment of the match
The game looked to be heading towards a goalless stalemate until Sanchez’s shot from a free-kick just on the edge of the area deflected into the net off of James McClean.
Replays showed that without the nick off the West Brom player the ball would probably have flew wide.
The rest of his team-mates celebrated with him this time, unlike at Crystal Palace.
Arsenal have a 100 per cent record against West Brom, having scored in all 24 of their Premier League games against the Baggies.
Ben Foster 6 (out of 10)
Craig Dawson 7
Ahmed Hegazi 7
Jonny Evans 5
Kieran Gibbs 6
Gareth Barry 5
Matt Phillips 5
Jake Livermore 6
Chris Brunt 5
Jay Rodriguez 7
Hal Robson-Kanu 6
James McClean (for Phillips, 72) 4
Grzegorz Krychowiak (for Brunt, 72) 4
Allan Nyom (for Robson-Kanu, 75) 5
Petr Cech 5
Calum Chambers 5
Shkodran Mustafi 4
Laurent Koscielny 6
Hector Bellerin 5
Jack Wilshere 6
Granit Xhaka 6
Sead Kolasinac 5
Alex Iwobi 7
Alexis Sanchez 6
Alexandre Lacazette 6
Ainsley Maitland-Niles (for Kolasinac, 38)
Per Mertesacker (for Koscielny, 72) 5
Danny Welbeck (for Iwobi, 74) 5