Here, Press Association Sport looks ahead to the main talking points ahead of the tie at the Jamtkraft Arena:
BIGGER GAME FOR WENGER THAN HE WOULD HAVE HOPED
Arsenal eased through the Europa League group with little difficulty as Arsene Wenger utilised his squad in a competition that was seen as inferior in their targets compared to the Premier League and FA Cup.
Now, however, the Gunners are a massive 27 points behind leaders Manchester City in the league and are struggling to make the top four while their ambitions of defending their FA Cup ended with a shock third-round exit at Nottingham Forest.
That means the Europa League now offers the most likely route back into the Champions League for Wenger and Arsenal, which is why a strong squad will be present on Thursday.
Wenger knows this may be his best chance of qualifying for the Champions League.
POTTER ATTEMPTING TO CONJURE UP MORE MAGIC
There has been much written about Ostersund’s manager since the draw was made late last year.
Graham Potter, a Midlander who played in defence for the likes of Birmingham, Stoke, Southampton and West Brom, has turned the Swedish side from lower-league minnows to top-flight cup winners.
Their Europa League adventure has included victories over established names such as Galatasaray, PAOK and Hertha Berlin and now they can add Arsenal to their ever-growing list of scalps.
Graham Potter has been making a mark in Sweden, but this is his big moment.
CAN GUNNERS COPE ON THE SLOPES?
Freezing conditions will greet the Arsenal squad when they disembark from their aircraft at Ostersund Airport.
Although not quite the -23°C of last month, it will still be a shock to the system – as will the compact stadium and artificial pitch.
Wenger is expected to bring some of his top names out to this Swedish outpost and their ability to adapt could prevent any embarrassments.
Ostersund will promise a raucous atmosphere – and cold weather.
HOME BOYS GIVEN A CHANCE TO SHINE
Jamie Hopcutt and Curtis Edwards are not household names in their native England but the pair have become integral to Potter’s plans at the Jamtkraft Arena.
Hopcutt, a 25-year-old midfielder, had unspectacular spells at York, Whitby, Ossett Town and Tadcaster before making the move to Scandinavia.
Middlesbrough-born Edwards had a similar adventure in England’s lower leagues as he turned out for Darlington, Spennymoor and Thornaby.
Now the duo can show they can cut it with the best that the Premier League has to offer as they aim to play their part in a major upset.
Curtis Edwards has been instrumental in Ostersund’s European campaign.
WELBECK TO BE GIVEN RARE OPPORTUNITY TO IMPRESS
With club-record signing Pierre-Emerick Aubameyang cup-tied and summer recruit Alexandre Lacazette injured, the chances are that Danny Welbeck will lead the line for Arsenal.
The former Manchester United man has struggled with injuries since his move to the Emirates Stadium but could now play his part in making sure the Gunners advance in Europe.
With Theo Walcott, Alexis Sanchez and Olivier Giroud leaving in the January window, Welbeck is now one of Arsenal’s established attacking players and the England international will be desperate to grasp his opportunity if it arises.
Danny Welbeck has yet another chance to shine in an Arsenal shirt.
