The Seagulls will want to pull off a surprise after suffering a 3-2 loss to Crystal Palace at the weekend.
As Spurs look to keep their bid for the top-four alive, we take a look at some key stats and facts ahead of what promises to be an entertaining clash.
– Brighton won their last home league match against Spurs, though it was back in April 1983 (2-1).
– In all competitions, Spurs have won each of their last three meetings with Brighton, scoring exactly twice each time.
– Tottenham have won seven of their last 10 Premier League games played on a Tuesday (D1 L2).
– The visitors are unbeaten in their last 34 Premier League games against newly promoted opposition, winning the last 16 in a row. Only Chelsea have ever had a longer unbeaten run against promoted sides in the competition (63, between 2001 and 2011).
– Three of Brighton’s four home defeats this season have been in games against ‘big six’ opposition.
– Should Tottenham win here, it will be the 12th different ground at which they’ve won a Premier League game this season – more than in any other campaign in the competition (also 11 in 2012/13 and 2013/14).
– Mauricio Pochettino’s side have won 33 points on the road in the Premier League this season (W10 D3 L4) – only champions Man City have earned more.
– Since the start of 2014/15, Harry Kane has scored 22 goals in 20 games against newly promoted sides. He’s also scored a hat-trick against one of them in each of the previous three seasons (Leicester in 2014/15, Bournemouth in 2015/16 and Hull in 2016/17).
– Glenn Murray hasn’t scored in his last two home Premier League games – he last went three without a goal at the Amex in the top-flight in his first three appearances there this season.
– Christian Eriksen has scored five goals and provided three assists in his last six away games for Tottenham in all competitions.
Statistics provided by Opta
September 5: Man City 5 Liverpool 0
After opening their campaign with three successive wins, City then made a serious statement with this thrashing of one of their chief rivals.
Sergio Aguero put them ahead and before Liverpool had Sadio Mane sent off following a collision with Ederson. Gabriel Jesus and Leroy Sane scored two each as the Reds were torn apart.
September 16: Watford 0 Man City 6
Arguably the performance that pleased the eye most all season, with City at their most fluid and exhilarating. Aguero scored a sublime hat-trick while there were further goals for Jesus, Nicolas Otamendi and – from the penalty spot – Raheem Sterling.
Within a few more weeks they had also thrashed Crystal Palace 5-0 and routed Stoke 7-2.
September 30: Chelsea 0 Man City 1
As well as demolishing some sides, Pep Guardiola’s men showed they could prise open the most stubborn of opponents. Their slender victory at Stamford Bridge was just such a case.
City dominated but it took a spectacular strike from Kevin De Bruyne to settle the affair.
November 26: Man City 2 Southampton 1
Having seen some of their rivals cut open by City in the early part of the season, teams began to adopt more defensive mindsets against them in the late autumn. It was a difficult spell, but ultimately City still prevailed, grinding out victories over Huddersfield, Southampton and West Ham.
The victory over Saints seemed psychologically critical, coming with a stunning Sterling winner deep into added time that sparked jubilant scenes.
December 10: Man Utd 1 Man City 2
The headlines may have been dominated by a post-match fracas outside the dressing room, but City took a decisive step towards the title by beating their rivals at Old Trafford to establish an 11-point lead at the top.
David Silva and Otamendi capitalised on defensive mistakes to secure victory for a dominant City either side of a Marcus Rashford strike.
December 16: Man City 4 Tottenham 1
De Bruyne produced an inspired display as City again showed their class by hammering Spurs. The Belgian got on the scoresheet after Ilkay Gundogan netted first while Sterling grabbed two more after Jesus missed a penalty.
March 1: Arsenal 0 Man City 3
The title race became a procession as Arsenal, for the second time in four days after losing the Carabao Cup final, allowed City to coast to victory at the Emirates Stadium.
Bernardo Silva, David Silva and Sane were on target as sublime City effectively got the job done inside 33 minutes.
Provided by Press Association Sport
The Gunners led at St James’ Park through Alexandre Lacazette’s 14th-minute strike, but a side featuring six changes from the one which drew in Moscow on Thursday evening to secure a Europa League semi-final berth eventually succumbed 2-1 to goals from Ayoze Perez and Matt Ritchie.
Disappointed manager Wenger said: “I think it’s very difficult to combine the Europa League on Thursday night and then playing Sunday morning. You play in Moscow, you come home, you play again away from home.
“This game is a bit special. On top of that, I must say the attitude of our team was spot on from the start.
“But it didn’t work and I have to be realistic enough to say that maybe our balance offensively and defensively doesn’t work.”
Asked if he was concerned that his team has not picked up a single point away from home since the turn of the year, the Frenchman said: “Of course it’s a concern because traditionally we have a very strong record away from home.
“It has a subconscious weight in our minds. Once you’re in a negative spiral like that, it’s very difficult to get out.”
Arsenal are the only team in England’s top four leagues who have failed to secure an away point in 2018.— BBC Sport (@BBCSport) 15 April 2018
Here’s how Arsene Wenger responded to today’s defeat.
👉 https://t.co/52bXKLjNPR pic.twitter.com/dubYCvyPS9
By contrast, Newcastle boss Rafael Benitez was in jubilant mood after his team eased past the 40-point survival target he set them at the start of the season, courtesy of a battling performance which saw them play second fiddle for long periods before launching a spirited fightback.
The Magpies are desperate to tie up the Spaniard to an extended deal with his current contract about to enter its final year, and while he was giving nothing away, the future is on his mind.
He said: “Today, I was really pleased with everything I have seen, but at the same time, we are professionals and we have to be sure that next year, we have the tools to compete at the level we want to compete at.
“As I have already said, we did not expect to be here at this stage of the season. We are really pleased with that and now we have to try to get higher in the table.”