United, buoyed by five successive Premier League victories, are confident they can restore red ascendancy in the city by avoiding a fifth successive derby defeat.
The Red Devils have more silverware in their trophy cabinet, but City have had the better of their local rivals during the last couple of years.
Despite City's recent success in derbies, United go into the match as favourites with Manuel Pellegrini's side having dropped down to fourth after their morale-sapping defeat at Crystal Palace on Monday and trail leaders Chelsea by nine points.
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