The Whites are hoping to pile more pressure on eternal rivals Barcelona, who face Leganes away (10pm).
Barca and Los Blancos are locked on 13 points each, with four wins and a draw apiece from their first five matches although Blaugrana remain top on goal difference.
Julen Lopetegui’s side will have to do without playmaker Isco though, who is set to be sidelined for a month having been diagnosed with acute appendicitis.
22 players will make the trip to Andalusia.
📝 Our 22-man squad for tonight’s LaLiga match against @SevillaFC_ENG! #RMLiga pic.twitter.com/2CPAjTeFRX
— Real Madrid C.F. 🇬🇧🇺🇸 (@realmadriden) September 26, 2018