The Premier League champions arrive at the Camp Nou after a 1-1 draw with the Catalans in the first leg.
Many believe Chelsea should’ve made more of their home advantage in the first leg and stand little chance of progress in Spain.
Fans from both sides of the fence made their predictions ahead of the encounter in the video below from Barcelona’s YouTube channel.
How do you think the contest will play out?
The two sides have had some highly engaging European battles over the years and their second leg clash promises to be no different.
Here, we take a look at the seven deadly stats centred around the two heavyweights.
9 – Remarkably, Chelsea are undefeated in their past nine matches against Barcelona in all competitions – with their last loss to Barcelona being way back in February 2006.
4 – At the Camp Nou, Barcelona have drawn the previous four meetings with the west Londoners – with the most recent of those coming in April 2012.
881 – Luis Suarez is enduring a goal drought in Champions League competition and has failed to find the back of net in 881 minutes, dating back to his strike against PSG 12 months ago.
6 – Willian will no doubt be a key man for the away side again and six of his last nine Champions League goals for the King’s Road side have come outside of the box (67 per cent).
8 – Having broken his duck against Chelsea in the first leg (his only goal in nine matches against the English outfit), Lionel Messi has now scored eight goals in his past five matches against opposition from the Premier League (18 in 27 in total).
13 – Out of the previous 13 meetings between the two sides, Barcelona have been victors thrice while Chelsea have won on four occasions. There have also been four draws with each team scoring 19 times apiece.
11 – Blaugrana are bidding to reach their 11th straight Champions League quarter-final and have won 19 out of 32 home European clashes with English sides in history. Interestingly, they’ve only ever lost two matches on home soil.
The Premier League side stifled the La Liga leaders at Stamford Bridge last month, with Blaugrana eventually coming away with a 1-1 draw thanks to a late Lionel Messi equaliser after Willian had put the hosts ahead.
It means it is set up perfectly as both teams look to advance to the quarter-finals. The big news for Barcelona is that Messi is back after missing the weekend win over Malaga due to being present at the birth of his third son.
Here, we look at the likely line-ups and team news before the two sides face off in Catalonia.
Club icon Andres Iniesta is set to shake off a troublesome hamstring injury and take his place at the heart of the hosts’ midfield in a welcome boost for Ernesto Valverde’s men. With Philippe Coutinho cup-tied, the experience of Brazilian Paulinho is likely to be preferred to raw talent Ousmane Dembele, who will be trusted to make a telling impact from the bench if necessary.
The Blues are set to resist the temptation to field either Alvaro Morata and Olivier Giroud in a chief striking role while the likes of Tiemoue Bakayoko, David Luiz and Ross Barkley are all set to be unavailable. Antonio Conte’s side picks itself but Davide Zappacosta could come in should Chelsea have to contend with any late injury worries.