A stunned Roger Federer was dumped from the Australian Open Friday in his worst showing since 2001 as Maria Sharapova, Andy Murray and Eugenie Bouchard battled to stay in the title hunt.
In the tournament's biggest upset, the Swiss world number two had no answer to unseeded Italian Andreas Seppi, who he had conquered in their past 10 meetings.
"Just a bad day. I wish I could have played better but clearly it was tough losing the first two sets," Federer said after crashing out in the third round 6-4, 7-6 (7/5), 4-6, 7-6 (7/5). "I had chances to get back into it but let it slip. It's a disappointing loss."
The defeat was the 17-time Grand Slam winner's earliest exit in Melbourne in 14 years and aside from his second round Wimbledon flop in 2013, was the Swiss legend's worst performance at a major in more than a decade.
"To beat Roger first time, especially in a Grand Slam, best-of-five, is a special moment for me," said the 46th ranked Seppi, who had only taken one set off him in their previous 10 matches.
In contrast, Sharapova blitzed her way past Zarina Diyaz of Kazakhstan 6-1, 6-1, erasing memories of the massive scare she was given in her second round clash when she had to save two match points.
"I started really focused, I knew I had a tough, long match previously, so I wanted to start off strong and finish strong," said the Russian second seed. "I think I did a good job of that."
Murray was also in form, easily beating Portugal's Joao Sousa. The Scot, who won 6-1, 6-1, 7-5, has yet to be seriously tested at Melbourne Park, with a first-match tiebreak the closest he has come to dropping a set.
He will next meet Bulgarian 10th seed Grigor Dimitrov, who struggled against 2006 Open runner-up Marcos Baghdatis with the fired-up Cypriot pushing him to five gruelling sets.
Dimitrov, Sharapova's boyfriend, looked headed for defeat when Baghdatis won the third set before rallying to claim an exhausting 4-6, 6-3, 3-6, 6-3, 6-3 victory.
"I'm not going to hide my excitement of winning the match because it meant a lot to me," he said.
Rising star Bouchard also progressed, but made heavy work of downing France's Caroline Garcia, taking 56 minutes to get through the first set before moving up a gear to win 7-5, 6-0.
"I don't think it was the prettiest tennis out there today," admitted the seventh seeded Canadian, who has a big fan base in Australia.
Bouchard is seen as one of the new generation tipped to take the reins from the old guard of Serena Williams and Sharapova, with Dimitrov regarded as a contender in the men's game.
Third seed Simona Halep, a quarter-finalist last year, limped through against American world number 258 Bethanie Mattek-Sands 6-4, 7-5 and will next meet Belgium's Yanina Wickmayer.
Czech seventh seed Tomas Berdych was a more convincing winner, powering past Serb Viktor Troicki while women's 10th seed Ekaterina Makarova also went through.