We've taken a trip down memory lane and revisited the Swiss's best showings on a tennis court.
These are the performances that went a long way to cementing his legendary status.
5) US Open 2005 Final - Federer defeats Agassi 6-3, 2-6, 7-6, 6-1
Playing the great American under the Flushing Meadows lights, in what was Agassi's last Grand Slam final, was a real treat for Federer and he produced some magical tennis to win his second title in New York.
It prompted 35-year-old Agassi to say: "I think Roger is the best I've played against. To watch him evolve has been amazing."
That's some compliment.
4) French Open 2009 4th Round - Federer defeats Haas 6-7 (4), 5-7, 6-4, 6-0, 6-2
This was undoubtedly the key match during Federer's run through to his one and only Roland Garros title.
Playing against his close friend Tommy Haas, the Swiss had to battle back from two sets down to keep his French Open dream alive.
The fact Rafael Nadal had exited the tournament at the same hurdle was obviously playing on Federer's mind but he dug deep when it mattered to finish the job strongly in the fifth.
3) London 2012 Olympics semi-final: Federer defeats Del Potro 3-6 7-6 19-17
The four-hour, 26-minute battle was the encounter of the tournament and longest tennis match in Olympics history.
Federer had to produce his greatest tennis to overcome an attacking onslaught from Juan Martin del Potro.
The third set, which spanned two hours and 43 minutes, took every ounce of energy and effort out of Federer as he finally prevailed on Centre Court.
For Federer, the manner of the semi-final victory must have almost felt like a final win and in truth he had little left in the tank as Andy Murray went on to thrash the Swiss in straight sets in the final.
It was true redemption for the Scot after losing to Federer in the Wimbledon final on the same court only a matter of weeks earlier.
2) Australian Open 2017 Final - Federer defeats Nadal 6-4, 3-6, 6-1, 3-6, 6-3
A few of you will be surprised that Federer's historic 18th Grand Slam victory didn't top the bill.
The maestro's Melbourne success was the stuff of dreams and probably the most memorable match of his entire career.
But, aside from his stellar comeback in the fifth set when he looked down and out, it was a victory which carried a lot more weight due to the nature of his return from injury and beating long-term nemesis Nadal.
Those factors certainly outweigh the overall performance of Federer.
1) Wimbledon 2012 semi-final - Federer defeats Murray 7-5 7-5 6-4
The Swiss star enjoyed a truly vintage Friday afternoon in the London sun and produced an absolute masterclass, particularly on serve, to reach his 10th Wimbledon final.
Federer was at his sheer best and took Murray apart in straight sets - dropping just 21 points on serve in two hours and seven minutes.
He also only faced one break point in the entire match - which came in the very first game of the semi-final.
RF's first serve percentage was around 80 per cent throughout and Murray could simply not lay a glove on him, as he backed this up with solid net and groundstroke play.
Federer went onto lose to Novak Djokovic in the final for the second consecutive year.