Arsene Wenger has struggled against Jose Mourinho down the years, winning just one of the 15 previous head-to-heads with the current Manchester United boss.
The two face-off yet again as Arsenal travel to Old Trafford on Saturday and that duel is just one of the talking points building up to the encounter.
Here are our top five talking points.
WENGER VS MOURINHO
The testy relationship between the United manager and his Arsenal counterpart has intrigued onlookers over the years, on the sidelines and away from it.
This will be the first time Mourinho has faced Wenger as United boss and does so two places and six points worse off than the fourth-placed Gunners. The Portuguese could do with a morale-boosting victory against Arsenal and his history certainly suggests he can.
Mourinho has never lost to Arsenal in the Premier League, with the 2015 Community Shield triumph the only time Wenger has beaten Mourinho in 15 attempts.
0 - Arsene Wenger has won none of his 11 Premier League encounters with Jose Mourinho (D6 L5). Preview. https://t.co/tgx7ttaZ7U
— OptaJoe (@OptaJoe) November 17, 2016
ROONEY RETURN?
Helping England to a 3-0 victory against oldest foes Scotland, picking up a knee injury and being plastered across the front and back pages – the last week has been frantic even by Wayne Rooney’s standards.
The 31-year-old apologised “unreservedly” to interim England boss Gareth Southgate, the Football Association and fans following the emergence of “inappropriate” images of him looking the worse for wear at a wedding party last weekend. Mourinho says that chapter is closed now and that his skipper is fit to face Arsenal.
The forward has a fine record against the Gunners and this would be a timely moment to continue that.
SHAW AND SMALLING ISSUES
The positivity of a 3-1 win at Swansea before the international break was diminished somewhat by the Mourinho’s barbed comments about Luke Shaw and Chris Smalling.
The pair’s pain threshold was seemingly called into question by the United boss, whose anger at the subsequent reporting about Smalling in particular was evident in Friday’s press conference.
Mourinho refused to talk about the England centre-back, who it is reported may not be play again before Christmas having broken a toe so badly in two places. Shaw, who was suffering pain in the leg he broke so horrifically in September 2015, is fully fit though.
Jose Mourinho: "Luke Shaw is a player that has my confidence and will play in this period of many matches - for sure." #MUFC
— Manchester United (@ManUtdUpdates_) November 18, 2016
SANCHEZ FITNESS
Wenger has been playing Alexis Sanchez as his main striker for much of the campaign to date and it has paid dividends as the former Barcelona man has already scored eight goals. But the 27-year-old could miss the trip to Old Trafford after suffering a hamstring injury while on international duty with Chile.
Sanchez bagged a brace in the 3-1 World Cup qualifying win over Uruguay while carrying the problem and he will be assessed by Arsenal’s medical staff having only returned to their London Colney training base on Friday.
“He is always OK,” Wenger joked. “It is a very difficult one because I am sure he will come back saying he is all right.”
Alexis Sanchez took part in full training today and will travel with the squad to Manchester. #afc pic.twitter.com/iPmgMrxcep
— afcstuff (@afcstuff) November 18, 2016
JENKINSON TO BE DRAFTED IN
Carl Jenkinson last started a Premier League game for Arsenal back in August 2014 but the right-back is set to deputise for the injured Hector Bellerin on Saturday.
Bellerin has been ruled out for four weeks with an ankle injury picked up in the North London derby before the international break. After two loan spells at West Ham and a serious knee injury, Jenkinson has made his return in the Champions League and League Cup and is now set to step in for Wenger’s men.
He will have bad memories of Old Trafford, having been sent off in an 8-2 defeat for the Gunners in 2011.
