Manchester United will be without injured duo Sergio Romero and Diogo Dalot for the Premier League trip to Burnley.
Dalot is recovering from a knee operation and Romero has been out with his own knee problem but both were expected to face Stoke in and under-23s match on Friday night.
Marcos Rojo is edging closer to a first-team return but Phil Jones will miss the trip to face Burnley.
Provisional squad: De Gea, Herrera, Smalling, Lindelof, Valencia, Pogba, Matic, Fellaini, Fred, Shaw, Lingard, Lukaku, Sanchez, Rashford, Grant, Young, McTominay.
Premier League clubs will complete their fourth round of fixtures this weekend before the first international break of the season.
Here, we look at five talking points from this week’s top-flight matches.
Mourinho must halt United’s slide
A third straight defeat in his side’s first four matches would have appeared implausible, but that is a prospect Jose Mourinho‘s troubled side face at Burnley on Sunday.
Manchester United could already be staring at a nine-point gap between them and the Premier League leaders when they head to Turf Moor and another poor result will drive speculation over the ‘Special One’s’ future into fever pitch.
Can Reds maintain their flawless start?
Liverpool can steal a march on their rivals by moving three points clear at the top of the table with victory at Leicester in Saturday’s lunch-time kick-off.
Jurgen Klopp‘s side, one of four aiming to extend their 100 per cent start, have yet to concede a goal, while striker Sadio Mane is gunning for his fourth in as many games. Leicester have won two of their first three and should give the Reds their toughest test yet.
Spurs out to draw Hornets’ sting
Watford’s maximum haul from their first three games has caught most by surprise and they will raise a few more eyebrows on Sunday if they become the first to topple Tottenham this season.
Mauricio Pochettino‘s side are chasing their fourth straight win after dismantling United last week and will be brimming with confidence for what promises to be an intriguing encounter at Vicarage Road.
Blues bid for revenge
Chelsea bid to extend their winning start at unbeaten Bournemouth and have a score to settle with the south-coast club. Eddie Howe’s side secured one of their best Premier League results, winning 3-0 on their previous visit to Stamford Bridge in January.
Pellegrini pulls no punches
Manuel Pellegrini has sought to give his players a much-needed jolt by declaring West Ham’s home clash with newly-promoted Wolves as a must-win game.
The rock-bottom Hammers are the only top-flight club yet to register a point after three straight defeats and former Manchester City boss Pellegrini can ill-afford another home defeat in his bid to win over the fans.
Manchester City have no fresh injury concerns ahead of Saturday’s Premier League clash with Newcastle at the Etihad Stadium.
The 1-1 draw at Wolves last weekend saw Kevin De Bruyne (knee), Danilo (ankle) and Claudio Bravo (Achilles) miss out and that trio remain sidelined.
Nineteen-year-old goalkeeper Aro Muric is set to be in the squad again having been on the bench at Molineux after being recalled from his loan at NAC Breda following the injury to regular number two Bravo.
Provisional squad: Ederson, Muric, Walker, Kompany, Stones, Otamendi, Laporte, Mendy, Delph, Fernandinho, Gundogan, Zinchenko, Sterling, Sane, D Silva, B Silva, Foden, Diaz, Mahrez, Aguero, Jesus.