Here, PA looks at some of the issues surrounding the match.
Chance for Sane to shine
The future of Germany international Leroy Sane remains uncertain, although City boss Pep Guardiola insists the player has not asked to leave. The winger wants more game time and has certainly had that in pre-season so this could be his opportunity, on a big stage, to prove his worth.
Early psychological boost
The two teams’ neck-and-neck title race last season was decided by the finest of margins, so any chance to gain an early advantage may help, especially Liverpool who lost just one match and finished with a record points tally for runners-up.
With City’s Sergio Aguero, Nicolas Otamendi and Gabriel Jesus having only returned to training on Wednesday following their Copa America exploits, Liverpool have extra motivation, although their pre-season results have been mixed.
Will Klopp go full throttle then?
No. Of his international stars manager Jurgen Klopp is only waiting for Sadio Mane, after his run at the Africa Cup of Nations with Senegal, to come back on Monday.
Goalkeeper Alisson Becker, Roberto Firmino (30 minutes) and Mohamed Salah (45 minutes) all got their first action in Wednesday’s win over Lyon despite only joining the squad on Monday, so are likely to only get short run outs again. Aside from that it should be Klopp’s first-choice defence and midfield.
Will there be any clues for the start of the Premier League?
Whom Klopp picks to partner Virgil Van Dijk in central defence will give an idea of who gets the spot against Norwich next Friday. Joel Matip has been preferred over Joe Gomez in pre-season and looks set to continue.
Guardiola has more of a balancing act as although all players apart from Fernandinho are available, many are well short in their preparations due to late returns because of international commitments.
Oleksandr Zinchenko looks like getting the nod at left-back ahead of Angelino with Benjamin Mendy still injured. New signing and long-term Fernandinho replacement Rodri could make his first start.
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