Red Devils boss Jose Mourinho will be looking to get one over his former club, while counterpart Antonio Conte aims to go one better than last season when his side were beaten by Arsenal in the showpiece event.
Here Press Association Sport looks at the main talking points heading into the Wembley clash.
Conte’s position as Chelsea boss has been a constant source of speculation for months, with the Italian cutting an increasingly unhappy figure at Stamford Bridge.
Having delivered the Premier League title in his first campaign at the helm, the 48-year-old was initially unhappy with the summer recruitment drive in west London.
Add to that poor results on the pitch, which led to finishing fifth in the table, and all pointers suggest the former Juventus midfielder will bow out at the end of the season. Winning the FA Cup would be a good way to go.
Mour silverware the aim for the ‘Special One’
Having delivered League Cup and Europa League success in his maiden season as United boss, Mourinho will now want to add the FA Cup to a second-place Premier League finish.
The Portuguese has 11 honours to his name during his time in England, including two stints as Chelsea manager, and success on Saturday will see him lift a second FA Cup.
It will also help silence some of the criticism of the playing style adopted by Mourinho at Old Trafford as the club target a record-equalling 13th FA Cup success.
Conte to do some forward thinking
The biggest selection dilemma facing Conte heading into the final is his decision as to who will start in attack for the Blues.
Alvaro Morata managed just 11 Premier League goals following his big-money move from Real Madrid and has struggled to make an impact when called upon.
Meanwhile, Olivier Giroud joined from Arsenal in the January window and has become an instant cult hero at Stamford Bridge and would be a popular choice to start at Wembley.
Jose could be out of Luk
While Conte has a decision to make over his preferred striker, counterpart Mourinho is sweating over the fitness of his leading man.
Romelu Lukaku has hit 27 goals in his first season at Old Trafford and scored in every round of the FA Cup until the semi-final win over Tottenham.
The former Chelsea forward is struggling with an ankle injury suffered in the recent win over Arsenal and Mourinho has already hinted the 25-year-old may only be fit enough for the bench.
Emotional afternoon for all involved
There are likely to be tributes aplenty to Ray Wilkins on Saturday following the former Chelsea and United midfielder’s death last month.
Wilkins was a much-loved figure within the game and represented both clubs during a stellar playing career before working on the backroom staff at Chelsea for some time.
United will be keen to lift the trophy as a mark of respect to former boss Sir Alex Ferguson, who is still recuperating after surgery on a brain haemorrhage a fortnight ago – while Chelsea will also want to toast former captain Roy Bentley, who died in April aged 93.
Provided by Press Association Sport
Bayern Munich came to his rescue, and the Colombian has thrived in Germany. So much so, that he’s regained his place among the best attacking midfielders in the game.
He tops our list of the best at his position – who else made the cut?
1. James Rodriguez, Bayern Munich
This season has brought James full circle. He earned a move to Real Madrid after a stunning showing at the 2014 World Cup. Having left Madrid on loan last summer, he heads into this year’s World Cup at the top of his game again.
2. Lorenzo Insigne, Napoli
There were so many things to love about Napoli this season, even if their title bid ultimately fell short. Insigne’s form was one of them, leading a thrilling attack with flair, skill and no little drive.
3. Heung-min Son, Tottenham
4. Nabil Fekir, Lyon
If anyone was worried that Fekir’s severe injury debacle would derail his progress, they needn’t worry anymore. The Frenchman has been absolutely superb this term, leading Lyon’s charge for a Champions League spot.
5. Christian Eriksen, Tottenham
Eriksen must have felt that Harry Kane and Dele Alli had been hogging the headlines for too long. It’s been a stunning season from the Dane, who also scored a hat-trick in a World Cup qualifying play-off to seal Denmark’s spot.
6. Douglas Costa, Juventus
It’s strange that Bayern Munich let him go to Juventus on loan in the first place. The Brazilian is certainly not complaining – he’s hit top form for the Serie A‘s best side. He’s going to make Bayern rue their decision someday.
7. Memphis Depay, Lyon
Cut free from the pressure and expectation at Manchester United, Memphis has thrived. He had a run of six games with either a goal or an assist at one point, making sure Lyon didn’t miss a beat when Fekir was injured.
8. Luis Alberto, Lazio
What Insigne did for Napoli this season, Alberto did for Lazio. Ciro Immobile and Sergej Milinkovic-Savic stole the headlines for the Rome team, but the Spaniard’s incisiveness and vision underpinned their play.
9. Paulo Dybala, Juventus
It says it all that a season where he scores twice as many league goals while recording nearly the same number of assists as the previous year is considered a disappointing campaign. Granted, Dybala hasn’t hit the heights of last season, but he’s still a rising star.
10. Raheem Sterling, Manchester City
It’s tempting to wonder how good Sterling’s season would have been had he been a better finisher. Would we be talking about him in the same breath as Mohamed Salah? Of all the players to have grown under Guardiola’s tutelage, the Englishman showcases it best.
Hyperbole? Absolutely. But not by much. City’s dominant season in the Premier League was a result of De Bruyne’s consistent brilliance in the centre of the park, a player so attuned to the demands of his manager and the vision behind a historic success.
The Belgian duly tops our ranking of midfield maestros in Europe’s top five leagues – see who else made our top 10.
1. Kevin De Bruyne, Manchester City
Only an unexpectedly stunning season from Mohamed Salah has kept De Bruyne from sweeping England’s end-of-season awards. City have a squad full of riches, but De Bruyne is the reason they’re champions.
2. David Silva, Manchester City
Speaking of that squad full of riches – was this Silva’s best season in a City shirt? He’s been so good for so long that it seems hard to believe, yet the Spaniard found another level this season to lead his side to the title.
3. Ivan Rakitic, Barcelona
Rakitic has had a resurgent year for Barcelona, often looking like the third-best player in his side behind Messi and Marc-Andre ter Stegen. He rediscovered himself this season after a few below-par campaigns.
4. Miralem Pjanic, Juventus
Pjanic cemented his status as the Serie A‘s best midfielder this season. He’s a player who can be a metronome when Juventus are recycling possession, and visionary and lethal in attack. And that’s before you get to his set-piece prowess.
5. Fernandinho, Manchester City
Pep Guardiola’s insistence on full-throttle attack from even his defenders makes Fernandinho City’s most important player. He’s still glued in to their possession football, but he’s also the rock that anchors their defence.
6. Jorginho, Napoli
It says it all that with Fernandinho at 33, Jorginho is the favourite to deputise and eventually replace him at City. The Brazil-born Italian has had an utterly superb season for Napoli.
7. Saul Niguez, Atletico Madrid
Another player who’s turning heads at Europe’s other leading clubs. Saul’s been a great find for Diego Simeone, an energetic midfielder with an eye for goal.
8. Geoffrey Kondogbia, Valencia
Kondogbia’s stock had dropped sharply going into this season, but he’s redeemed himself just as his team have. Valencia have gone from relegation battlers to the top four, and Kondogbia’s been vital to that transformation.
9. Radja Nainggolan, Roma
He shoots as if his foot is a cannon, bulldozes through midfield like a tank, and runs like he’s a literal engine. Calling him a one-man army might be a disservice to the rest of Roma’s midfield, but he’s been their heartbeat this season.
10. Dani Parejo, Valencia
Much like Kondogbia, Parejo has embodied Valencia’s resurgence. This is a player who started off at Real Madrid but never quite seemed to be good enough for that level. He’s put that theory to bed this season.