Jurgen Klopp saw his Europa League bow with Liverpool end in frustration, on a night when his former club Borussia Dortmund took control of their group.
Klopp's first Anfield match ended in a 1-1 draw against Rubin Kazan despite the Russians playing 54 minutes with 10 men following Oleg Kuzmin's sending off.
Liverpool were trailing to Marko Devic's effort at that stage, but Emre Can equalised within seconds of the red card.
FC Sion therefore took a four-point lead at the top of Group B having won 1-0 at 10-man Bordeaux.
Klopp's former charges sit three points to the good on top of Group C, Pierre Emerick-Aubemeyang securing a 3-1 win with a hat-trick, while PAOK and Krasnodar went goalless.
In-form Napoli continued a 100 per cent record in Group D, Manolo Gabbiadini (two), Jose Maria Callejon and Gonzalo Higuain notching in a 4-1 success over Midtjylland.
Group E leaders Rapid Vienna and Group F pace-setters Braga have also won all three of their matches after both edged five-goal thrillers.
The Austrians came out on top of Viktoria Plzen, with Alan grabbing an 89th-minute winner for Braga against Marseille.
Villarreal nestle second behind Rapid, Cedric Bakambu's brace setting up a 4-0 defeat of Dinamo Minsk.
Ole Gunnar Solskjaer's return as Molde manager was a cause for celebration as the Group A leaders eased to a 3-1 win at Celtic's expense.
Fenerbahce got their first victory in the group's other game, Fernandao netting in the 89th minute.
Stefano Okaka struck the decisive goal as Anderlecht came from behind to inflict a first defeat of the Europa League group campaign on Tottenham.
Christian Eriksen put Spurs in front after just four minutes but Guillaume Gillet levelled soon after and Okaka – on loan from Tottenham's London neighbours Fulham – sealed a first victory for the hosts with 15 minutes remaining.
Lacina Traore's goal was enough for Monaco to edge past FK Qarabag and leapfrog Tottenham at the Group J summit.
Lazio took a three-point lead in Group G after defying an early red card to beat Rosenborg 3-1 at Stadio Olimpico.
Mauricio was dismissed after only six minutes but Alessandro Matri, Felipe and Antonio Candreva (below) netted for the Serie A side in a match that saw missed penalties at both ends.
Dnipro had been level on points with Lazio but lost 1-0 at home to St Etienne, with Romain Hamouma on target.
Schalke remain atop Group K after a 2-2 draw with second-placed Sparta Prague, while APOEL Nicosia beat Asteras Tripolis 2-1.
Sporting were the evening's big scorers in Group H, despatching Albanian outfit Skenderbeu 5-1, with all six goals coming after Hamdi Salihi's first-half sending off.
Top two Lokomotiv Moscow and Besiktas shared a draw, with goals from Maicon and Mario Gomez.
There were two unexpected away wins in Group I. Lech Poznan celebrated a 2-1 success at Fiorentina, Dawid Kownacki and Maciej Gajos negating Giuseppe Rossi's late consolation, with Portugal's Os Belenenses surprising Basel by the same scoreline.
In Group L Augsburg got off the mark in style, Piotr Trochowski's goal enough to defeat AZ Alkmaar at home.
Athletic Bilbao ended Partizan Belgrade's 100 per cent record as Raul Garcia and Benat Etxebarria effected a 2-0 win for the visitors.
Legia Warsaw against Club Brugge and Liberec versus Groningen both ended 1-1.
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