Raheem Sterling has withdrawn from the England squad for the internationals with Spain and Switzerland due to injury.
Manchester City forward Sterling has suffered a back problem, according to a statement from the Football Association.
Gareth Southgate’s Three Lions host Spain in the UEFA Nations League at Wembley on Saturday, before taking on the Swiss in a friendly at Leicester’s King Power Stadium three days later.
Manager Southgate, who celebrated his 48th birthday on Monday, does not plan to call up a replacement.
The remaining 21 players in the squad are due to train for the first time on Tuesday morning at St. George’s Park.
Sterling has scored twice in three Premier League appearances for City so far this season, including the opener in Saturday’s victory over Newcastle.
The 23-year-old has won 44 caps for his country, scoring twice, and made six appearances at the World Cup in the summer as England reached the semi-finals.
Tottenham goalkeeper Hugo Lloris has been ruled out of France’s clash with Germany through injury.
Lloris missed his side’s 2-1 defeat at Watford on Sunday with a thigh problem and will also be unavailable for France’s Nations League opener on Thursday.
France boss Didier Deschamps called up Montpellier goalkeeper Benjamin Lecomte to replace Lloris after the 31-year-old was examined by Dr Franck Le Gall at France’s National Football Centre at Clairefontaine on Monday morning.
Lloris apologised “wholeheartedly” last month after being charged with drink driving.
The World Cup winner was charged following a routine patrol stop in the early hours of Friday, August 24 and was bailed to appear at Westminster Magistrates’ Court on September 11.
Lloris said in a statement: “I wish to apologise wholeheartedly to my family, the club, my team-mates, the manager and all of the supporters.
“Drink driving is completely unacceptable, I take full responsibility for my actions and it is not the example I wish to set.”
Atletico Madrid striker Diego Costa has withdrawn from the Spain squad for the Nations League matches against England and Croatia, with Celta Vigo’s Iago Aspas coming in as a replacement.
In a statement released on Monday, the Spanish Football Federation said Costa was “on leave for personal reasons”.
Costa and Aspas, who were both part of Spain’s World Cup squad over the summer, played against each other on Saturday as Atletico lost 2-0 at Celta.
Costa played the full duration of the LaLiga contest, in which Aspas netted the second goal.
Aspas scored in Spain’s last meeting with England, a 2-2 draw at Wembley in November 2016.
The teams face each other at the same venue on Saturday in what will be La Roja’s first match under new boss Luis Enrique.
Spain then take on Croatia three days later at Elche’s Estadio Martinez Valero.