The Nations League finals line-up will be set in the current international break, along with promotion and relegation.
Here, Press Association Sport looks at how the first round of fixtures can affect the key issues.
A:1 France, Holland, Germany
France can clinch the group with a point against Holland on November 16. A Holland win would condemn Germany to relegation.
A:2 Belgium, Switzerland, Iceland
Iceland are relegated regardless of November 15’s result against Belgium. Top spot in the group will not be decided until the final match between Switzerland and Belgium.
A:3 Portugal, Italy, Poland
Portugal need only a draw in Italy to seal the group with a game to spare. Poland are already relegated.
A:4 Spain, England, Croatia
Spain will seal a place in the finals if they win against Croatia.
B:1 Ukraine, Czech Republic, Slovakia
Ukraine are already promoted, while the relegation battle will go down to the final game.
B:2 Russia, Turkey, Sweden
Turkey will be relegated if they lose to Sweden. That is also the only result that can prevent – or at least delay – Russia winning the group.
B:3 Bosnia and Herzegovina, Austria, Northern Ireland
Bosnia and Herzegovina need only a point against Austria to guarantee promotion. Northern Ireland will be relegated unless Austria lose.
B:4 Denmark, Wales, Republic of Ireland
Wales and Denmark go head to head with the winner taking the group. The Republic will be relegated unless Denmark lose.
C:1 Israel, Scotland, Albania
Albania will be relegated if they lose to Scotland. Promotion will go down to the final game.
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C:2 Finland, Greece, Hungary, Estonia
Finland need only a point against Greece to be promoted. Estonia need a win – or at least a 3-3 draw – against Hungary to have any hope of avoiding relegation.
C:3 Bulgaria, Norway, Cyprus, Slovenia
Defeat to Norway would see Slovenia relegated to League D. The promotion battle will go down to the final round of games.
C:4 Serbia, Montenegro, Romania, Lithuania
Lithuania must beat Romania – either by two clear goals or while scoring at least three – to have any hope of avoiding relegation. Serbia can clinch the group if they beat Montenegro and Romania fail to win.
D:1 Georgia, Kazakhstan, Latvia, Andorra
Georgia have already clinched promotion.
D2: Luxembourg, Belarus, Moldova, San Marino
Luxembourg will be promoted if they beat Belarus.
D:3 Kosovo, Azerbaijan, Faroe Islands, Malta
Kosovo will be promoted if they win in Malta and Azerbaijan do not beat the Faroe Islands.
D:4 Macedonia, Liechtenstein, Armenia, Gibraltar
Macedonia can wrap up the group with victory over Liechtenstein, but only if Gibraltar and Armenia draw.