Leaders, on goal difference, Barcelona host Sporting Gijon at the Camp Nou while Real Madrid travel to city rivals Rayo Vallecano on Saturday night.
These two matches fall either side of Atletico Madrid’s home clash with Malaga.
And here’s our video guide to everything you need to know this weekend.
#LaLiga no se detiene...
— LaLiga (@LaLiga) April 22, 2016
Consulta dónde ver los partidos de esta jornada en tu país. https://t.co/jIfgiuzret ?? pic.twitter.com/8AlZPGvauM