The two sides are yet to get off the mark in Group B so far and both are desperate for a victory to keep their hopes of progressing alive.
Here, Press Association Sport focuses on the Dutch side.
FORM
In domestic terms PSV are probably the most in-form team in Europe. Nine games into their Eredivisie campaign they still have a 100-per-cent record, a five-point gap at the top of the table and a goal difference of plus-33. Mark van Bommel’s side have won their last two matches 4-0 and 6-0.
PEDIGREE
PSV enjoyed two golden eras revolving around a UEFA Cup victory in 1978 and a European Cup win in 1988. They have won the Eredivisie title 24 times and the KNVB Cup nine times.
#UCL is back in Eindhoven! 🏆#PSVTOT pic.twitter.com/us1c6viTiE
— PSV (@PSV) October 23, 2018
PREVIOUS MEETINGS
The sides met in the last 16 of the UEFA Cup in 2008 when, having lost the first leg 1-0 at White Hart Lane, Spurs levelled the tie on aggregate thanks to Dimitar Berbatov’s late equaliser. It went to penalties and Jermaine Jenas had a chance to win the shootout but his effort was saved by Heurelho Gomes before Pascal Chimbonda put the 14th spot-kick wide.
STAR MAN
Steven Bergwijn is a pacy winger who is reportedly on the radar of Manchester United and Liverpool. The 21-year-old has scored four goals in 11 matches this season and made his international debut for Holland in the 3-0 win over Germany earlier this month.