Manchester City, Liverpool and Barcelona are among the clubs bidding to reach the Champions League quarter-finals this week.
Here, Press Association Sport takes a look at the main talking points.
City keep eyes on big prize
Manchester City have been installed as favourites to lift the trophy after two late away goals clinched them a roller-coaster 3-2 first-leg win over Schalke.
City are under investigation by both UEFA and the Premier League for allegedly breaching financial fair play rules and the club’s hierarchy will be anxious to keep the spotlight focused on the team’s exploits.
Pep Guardiola’s side chase their 10th straight win in all competitions, but fans will be wary as Schalke posed a serious threat in Gelsenkirchen.
Klopp plots compatriots’ downfall
Liverpool’s last-16 tie against Bayern Munich hangs in the balance after a goalless draw at Anfield in the first leg. Jurgen Klopp’s side spurned several chances to eke out an advantage and the Germans must start as favourites for the return.
In Champions League history, only 10 of the 31 sides held at home in the first leg of a knockout match have progressed.
Bayern have lost only two of their last 26 home ties in the tournament, but Liverpool excel on the counter-attack and Klopp will relish the challenge in his homeland.
All eyes on Ronaldo
Juventus, two-time winners and beaten finalists in 2015 and 2017, face an uphill battle against Atletico Madrid in Turin.
The Bianconeri must overturn a 2-0 first-leg deficit and will be pinning their hopes on Cristiano Ronaldo, so often the architect of the Spanish club’s downfall during nine years at Real Madrid.
The Portuguese, rested in Juve’s 4-1 weekend win against Udinese, has scored 22 goals in 33 appearances against Atletico and aims to be the catalyst in an Italian fightback.
Barca odds-on to keep treble hopes alive
Lopes kept Barca at bay in the first leg.
Barcelona are on course for a La Liga, Copa del Rey and Champions League treble and barring a major upset will secure a place in the last eight of the tournament for the 11th successive season.
Lyon’s Anthony Lopes produced a goalkeeping masterclass as the first leg in France ended goalless, but Barca have since enjoyed successive cup and league wins over arch-rivals Real Madrid.
And, seven points clear at the top of their domestic table, they appear to be hitting their straps at the business end of the season.
