A record-breaking first-half performance laid the foundations for the Raptors, who had surged into a 76-58 lead at halftime to leave Washington chasing an 18-point deficit after the break.
DeRozan, who also contributed four assists and five rebounds, spearheaded a rampant Toronto offense, which saw six players finish with double-digit points tallies.
“I just let the game come to me,” DeRozan said afterwards. “It’s not like I go out there thinking I have to score 30 or 40 points. Tonight I just wanted to be aggressive.”
Jonas Valanciunas scored 19 points, while C.J. Miles had 18 off the bench as Toronto took a firm grip on the series with game three set for Washington on Friday.
“We’re strong as a team, it’s not about individual players,” Valanciunas said. “We did it as a team tonight. We were great defending, helping each other. It’s a team sport and when you play together and support each other it’s fun.”
Washington’s resistance was led by John Wall with 29 points, but the Wizards were rarely in the contest, save for one late rally as the top-seeded Raptors eased up.
Wall had given Washington hope of a recovery after draining two free throws to take the Wizards back to within five points at 108-103 in the fourth quarter.
But Toronto slammed the door shut with a rapid burst of scoring to take the game away from the Wizards for good as the clock wound down.
Earlier, the Raptors wasted no time in forging ahead during a lop-sided first half. Toronto powered into a 24-11 midway through the first period and were soon 34-13 up.
Toronto maintained a 20-point cushion through most of the first half, and they quickly passed their franchise record points tally of 63 to finish on 76 as the halftime buzzer sounded at the Air Canada Center.
Elsewhere on Tuesday, second seeds Boston shrugged off their injury crisis to down Milwaukee 120-106 to take a 2-0 lead in their first round series.
The Celtics are still reeling from confirmation that star Kyrie Irving will miss the rest of the season.
But the Boston club produced a dominant display to seal a win that puts them firmly in the driving seat in the best-of-seven series.
Jaylen Brown shouldered the offensive burden in the absence of Irving, scoring 30 points in 33 minutes on court.
Brown said the Celtics had been unfazed by the raft of injuries that has threatened to derail their season.
“I don’t pay attention to that, ultimately we just want to win games,” Brown said. “We’re confident as ever. Teams have been writing us off all year and we just keep proving people wrong.”
Terry Rozier had 23 points with eight assists on a night when six Celtics put up double figures.
Giannis Antetokounmpo led the scoring for the Bucks with 30 points, with Khris Middleton adding 25 in a losing effort.
In Portland, New Orleans took a 2-0 lead in their series against the Trail Blazers with a 111-102 victory on the road.
Jrue Holiday scored 33 points for the Pelicans – including 12 in a fourth quarter rally – to guide New Orleans home, with Anthony Davis adding 22.
C.J. McCollum led the scoring for the Blazers with 22 points, while Damian Lillard was effectively nullified by the Pelicans defense, scoring just 17 points.
Know more about Sport360 Application