The Green Bay Packers fired head coach Mike McCarthy as a Mason Crosby missed field goal saw the Green and Gold slump to their third straight NFL loss.
Aaron Rodgers completed 31 of 50 for 233 yards and a touchdown, but his 35th birthday was to end in disappointment as Crosby hooked his 49-yard attempt wide as time expired.
Zane Gonzalez had put the Arizona Cardinals 20-17 ahead with 1:41 left to play and the loss meant Green Bay have a 4-7-1 record for the season leading to the departure of McCarthy, head coach since 2006 and Super Bowl winner in 2010.
The Los Angeles Rams clinched the NFC West title for the second season in a row, with Todd Gurley rushing for 132 yards and two scores in a 30-16 win over the Detroit Lions.
A three-point game going into the fourth quarter, Gurley sealed the win after muscling his way into the end zone with two minutes left on the clock.
The league’s other LA team, the Chargers, came back from 23-7 down to pip the Pittsburgh Steelers 33-30, after Mike Badgley scored a field-goal at the third time of asking.
With three seconds left on the clock, Badgley missed from 39 and 34 yards, but offside penalties were called against the Steelers. He made no mistake from 29 to secure the win.
Patrick Mahomes threw four touchdowns as the Kansas City Chiefs saw off the Oakland Raiders 40-33, the Chiefs making light of the loss of star running back Kareem Hunt, who they released earlier in the week following an altercation with a woman in a Cleveland hotel earlier this year.
Josh Allen had two scores and rushed for 135 yards but the Buffalo Bills went down to divisional rivals the Miami Dolphins 21-17.
Another AFC East side, the New York Jets, capitulated in Nashville, leading 16-0 but going down 26-22 to the Tennessee Titans to record their sixth loss in a row.
The Jets had a pick-six, blocked a punt and a point after attempt but their defence crumbled in the fourth quarter with Marcus Mariota finding Corey Davis for the game-winning touchdown with 36 seconds left.
Overtime was needed in New Jersey as the New York Giants blew a 10-point lead late in the fourth but won 30-27 over the Chicago Bears with an Aldrick Rosas 44-yard field goal.
The Jacksonville Jaguars restricted the Indianapolis Colts to 265 yards in a shutout 6-0 win, while the Houston Texans D-Line forced four turnovers from the Cleveland Browns in their 29-13 victory.
Cam Newton threw for two touchdowns and 300 yards, but was picked off four times as the Carolina Panthers went down 24-17 to the Tampa Bay Buccaneers, while Tom Brady passed 1,000 career rushing yards in his 19th season as the New England Patriots beat the Minnesota Vikings 24-10.
The Seattle Seahawks saw off the fading San Francisco 49ers 43-16, the Atlanta Falcons lost their fourth in a row 26-16 to the Baltimore Ravens and the Denver Broncos kept up their purple patch with a 24-10 win over the Cincinnati Bengals, Phillip Lindsay rushing for two touchdowns.
The Green Bay Packers have fired Mike McCarthy, their head coach since 2006.
McCarthy led the Pack to Super Bowl 45 victory against the Pittsburgh Steelers but the side have struggled this season.
They currently have a 4-7-1 record and are third in the NFC North.
President and chief executive officer Mark Murphy said: “The 2018 season has not lived up to the expectations and standards of the Green Bay Packers.
“As a result, I made the difficult decision to relieve Mike McCarthy of his role as head coach, effective immediately.
“Mike has been a terrific head coach and leader of the Packers for 13 seasons, during which time we experienced a great deal of success on and off the field.”
In a statement, the team said he would be released “immediately” and accused the NFL’s reigning rushing champion of not being truthful when members of the management team spoke to him about the incident earlier this year.
The NFL had earlier announced that Hunt had been placed on the commissioner exempt list, which banned him from practising as well as playing in or attending games.
Footage of the incident, said to have taken place on February 10 at a hotel in Cleveland, was published online on Friday. According to reports, police were called to the scene but no charges were filed.
The Chiefs said: “Earlier this year, we were made aware of an incident involving running back Kareem Hunt.
“At that time, the National Football League and law enforcement initiated investigations into the issue.
“As part of our internal discussions with Kareem, several members of our management team spoke directly to him. Kareem was not truthful in those discussions. The video released today confirms that fact. We are releasing Kareem immediately.”
In a statement to ESPN, Hunt said he wanted to “apologise for my actions”, adding: “I deeply regret what I did. I hope to move on from this.”
The 23-year-old was drafted by the Chiefs in the third round of the 2017 Draft. He has been in sublime form for the 9-2 Chiefs – helping them to one of the best records in both the AFC and NFL overall.
Hunt has rushed for 824 yards this season, which is fifth most, while his seven rushing touchdowns is joint sixth. He also has seven receiving touchdowns too from 26 grabs for 378 yards.