The 37-year-old Briton announced on his Sirius XM radio show that the fight against American veteran Henderson will take place in Manchester on October 8.
“Dan Henderson vs. Michael Bisping for the 185 pound middleweight title, October 8 from Manchester – live on pay-per-view. Do not miss it,” Bisping said.
The fight gives Bisping the chance to avenge a vicious second-round knockout defeat by Henderson at UFC 100, a KO which many have considered to be the best in the sport’s history.
He said: “Why would I want to avenge the most devastating knockout in UFC history? I just don’t know why I would do that?
“Chris Weidman, Luke Rockhold, Jacare – they’re going nowhere. Dan Henderson is on the verge of retiring; he said one more fight. So, Dan Henderson, put your big boy pants on, fly over to Manchester and I’ll see you in the Octagon my friend.”
In June, Bisping became the first British fighter to win a UFC title when, on two weeks’ notice, he avenged another defeat with a first-round KO over Luke Rockhold at UFC 199. Bisping had lost to the American in 2014.
For Henderson, the fight against Bisping will be the last bout in the 45-year-old’s decorated career as he looks to claim a first UFC crown at the third attempt.
Bisping against Henderson will headline the card with other match-ups still to be announced.