Clermont scrum-half Parra suffered a sprain to his left leg playing in the loss to Bordeaux-Begles in the European Champions Cup which also left teammate Vahaamahina injured.
Bordeaux’s Serin, 21, is the tenth uncapped player called up to the training camp, which got underway at Marcoussis, outside Paris on Monday.
Parra, 27, who has 66 caps, underwent tests on Monday, with Vahaamahina, 24, who has 16 caps, also undergoing tests, although his injury was not revealed.
He will be replaced by 26-year-old Racing 92 flanker Le Roux, who has 23 caps, but who was not included in France coach Guy Noves’s initial list because he is getting married on February 13, the day of their second match against Ireland.
Montpellier winger Marvin O’Connor has earned a call up into the 31-strong France training squad for the Six Nations tournament following an injury to Benjamin Fall. The 24-year-old O’Connor has played for the France Sevens team but this is his first call up at the top level. The son of an Australian rugby league player who transferred to France, he has also played for his country at youth level.
The squad, the first one named by new national coach Guy Noves, will gather Sunday at the French rugby training centre near Paris to begin preparations for France’s Six Nations opener against Italy on February 6.
Dylan Hartley’s imminent promotion to England captain has the full support of one of the players eye-gouged by the Northampton hooker nine years ago.
Hartley is expected to be named as Eddie Jones’ skipper for the RBS 6 Nations on Monday afternoon despite a dire disciplinary record comprising of over a year’s worth of suspensions.
Among his offences is gouging the eyes of Wasps forwards James Haskell and Johnny O’Connor in 2007, an act that resulted in a 26-week ban.
Haskell, however, would welcome the appointment of the combative 29-year-old as Chris Robshaw’s successor, stating he “could not care less” about his indiscretions.
“If you are the best guy for the job you lead by example and you play. Your track record doesn’t matter,” Wasps captain Haskell said.
“There might be a few people with stiff collars who will get upset, but that’s the nature of the game. You live and die by the sword.
“Dylan is a good man and a good player. You know he will give 100 per cent and I could not care less what he has done before.”
Jones will speak to his senior players at the squad’s Surrey training base on Monday before officially announcing who will be at the helm for England’s rebuilding phase following a disastrous World Cup.
“I have played with Dylan since England Under-19s and gone all the way through with him. He is a good man and abrasive, which is what you want,” Haskell said.
“He is always committed to what he does and he would be a good captain. He captained Saints for a long time and commands respect from the boys.
“He expects everyone to toe the party line. He’ll lead by example and his passion for the shirt is renowned.
“I love Dylan and he is a good friend of mine. You pick the players to do a job. I am not particularly conformist myself. I do not worry too much about people’s opinions.
“Whoever is made captain, the rest of the team will have to get behind him and that is what we will do.”
England have called up Semesa Rokoduguni to their squad for the RBS 6 Nations as cover for Chris Ashton.
With Saracens having until Monday afternoon to appeal the 10-week ban issued to Chris Ashton for making contact with the eye area of Ulster centre Luke Marshall, head coach Eddie Jones has opted to summon Rokoduguni to the Red Rose training camp.
Rokoduguni, who last week signed a new two-year deal at Bath, won his solitary cap against New Zealand in 2014 before falling out of favour under the previous regime.
If Saracens decline to appeal or their effort to contest Ashton’s ban fails, the 28-year-old Fijian-born flyer will compete with Anthony Watson, Jack Nowell and Marland Yarde for the two wing berths.
England’s Six Nations squad gathered at their Surrey training base on Sunday night with Leicester’s contingent due to arrive on Monday morning following their Champions Cup match against Stade Francais in Paris.
Jones, once he has discussed the matter with his senior players, is expected to name Dylan Hartley as his captain on Monday
Outlining England’s schedule for the week, Jones said: “We’ll have a small chat about where we need to go and then we’ll get on with it. We’re not going to talk too much, we’re going to do.
“There are some clear things we need to address in the team, areas of how we want to play, how we want to operate, but it won’t be a grand address. I’m too old for powerpoints. It will be whiteboard.
“Monday will be installation day, very slow-paced, just organisational. Tuesday we’ll have a pretty good hit-out.
“Wednesday is recovery and Friday is at Twickenham, where we’ll have a really good attacking session. Saturday will be organisational.”