Fly-half Dan Biggar, who missed the opening Six Nations games against Scotland and England due to a shoulder injury, replaces Rhys Patchell in the number 10 shirt.
Elsewhere, full-back Leigh Halfpenny has recovered from a foot infection that ruled him out of Wales’ 12-6 defeat to England 10 days ago and replaces Gareth Anscombe, while fit-again Saracens wing Liam Williams takes over from Josh Adams.
“It is great to be able to bring so much experience back into the starting XV and into the backline,” said Gatland.
“We have been pleased with the depth we have developed in the back-three and pleased with how those players have gone but having the experience of Dan, Liam and Leigh coming back in is hugely important.”
Wales team: Halfpenny (Scarlets); L Williams (Saracens), S Williams (Scarlets), Parkes (Scarlets), S Evans (Scarlets); Biggar (Ospreys), G Davies (Scarlets); R Evans (Scarlets), Owens (Scarlets), Lee (Scarlets), Hill (Dragons), AW Jones (Ospreys capt), Shingler (Scarlets), Navidi (Cardiff Blues), Moriarty (Gloucester).
Replacements: Dee (Dragons), W Jones (Scarlets), Francis (Exeter Chiefs), B Davies (Ospreys), Tipuric (Ospreys), A Davies (Scarlets), Anscombe (Blues), North (Northampton).
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