Novak Djokovic succumbed to a shoulder injury as his US title defence came to an end against Stan Wawrinka.
Meanwhile, Johanna Konta knocked out the third seed to reach a third successive grand slam quarter-final and her first in New York.
Here, PA looks back at day seven and forward to day eight at the US Open.
Shot of the day
Madison Keys bowed out but not before unleashing this forehand rocket against Elina Svitolina.
Stat of the day
Konta is the first British woman since Jo Durie in 1983 to reach the quarter-finals at Flushing Meadows.
Shock of the day
Djokovic’s defeat was a surprise, but he has been carrying an injury. The shock came when women’s second seed Ashleigh Barty fell by the wayside, going down in straight sets to an inspired Qiang Wang of China.
Quote of the day
“Yesterday I did my laundry at a laundromat in Brooklyn. I’m very special when it comes to laundry” – Grigor Dimitrov keeps it real
Villain of the day
Daniil Medvedev is still rubbing the Flushing Meadows crowd up the wrong way.
Fallen seeds
Women: Ashleigh Barty (2), Karolina Pliskova (3), Madison Keys (10), Petra Martic (22)
Men: Novak Djokovic (1), David Goffin (15)
Order of play
Arthur Ashe Stadium:
Naomi Osaka v Belinda Bencic
Alexander Zverev v Diego Schwartzman
Marin Cilic v Rafael Nadal
Taylor Townsend v Bianca Andreescu
Louis Armstrong Stadium:
Donna Vekic v Julia Goerges
Andrey Rublev v Matteo Berrettini
Kristie Ahn v Elise Mertens
Gael Monfils v Pablo Andujar
Provided by Press Association Sport
