Which matches are you most looking forward to seeing on day four and who do you think will progress to the third round from our picks?
Have your say and share with us your predictions by commenting below, using #360fans on Twitter or getting in touch via Facebook.
ANDY MURRAY (GBR) vs MARCEL GRANOLLERS (ESP)
MURRAY vs GRANOLLERS
Murray and Granollers grew up together in the junior ranks but on Tour, the Scot is in a class apart.
The only time Granollers registered a win over Murray was when his opponent pulled out in Rome with a bad back.
No shock expected.
SPORT360 VERDICT: Murray in straight sets.
SERENA WILLIAMS (USA) vs VANIA KING (USA)
There were concerns about Serena’s shoulder but she put that to rest with a straight sets win over Ekaterina Makarova.
Her opponent King hasn’t made the third round of a Grand Slam since 2012 and that should stay unchanged.
SPORT360 VERDICT: Serena in straight sets.
STANISLAS WAWRINKA (SUI) vs ALESSANDRO GIANNESSI (ITA)
WAWRINKA (SUI) vs GIANNESSI (ITA)
Wawrinka enjoys playing in New York, having reached the quarter-finals or better in his past three appearances.
He was clinical in his win over Fernando Verdasco and should not find it too difficult against the Italian qualifier.
SPORT360 VERDICT: Wawrinka in straight sets.
VENUS WILLIAMS (USA) vs JULIA GÖRGES (GER)
Venus was not at her best against Kateryna Kozlova, as she was taken to three sets following a spate of unforced errors.
She will have to be at her best against Julia, who has a point to prove after falling out of the top 50.
SPORT360 VERDICT: Venus in three.
JUAN MARTIN DEL POTRO (ARG) vs STEVE JOHNSON (USA)
DEL POTRO (ARG) vs JOHNSON (USA)
Del Potro will be hoping his dream run, as far as fitness is concerned, continues as he takes on American Johnson.
Del Potro didn’t show any fitness issues in his win over Diego Schwartzman and should take this one..
SPORT360 VERDICT: Del Potro in five.
