Novak Djokovic admits his ultimate goal is to overhaul rivals Roger Federer and Rafael Nadal and hold the record for most grand slam titles.
Federer is currently out in front with 20 major men’s singles titles to his name, but at 38 his chances of adding to that tally are dwindling.
Nadal, 33, is two behind the Swiss and Djokovic currently has 16 following his epic Wimbledon win over Federer last month.
The Serbian is favourite to defend his US Open title over the next fortnight to move onto Nadal’s shoulders, and into Federer’s rear-view mirror.
“It’s still a very long way ahead of me,” he said. “It does also put a certain level of responsibility to me as well, because I am aiming to do that.
“You know, it’s definitely one of my ambitions and goals, if you want.
“I am 32. So things are a little bit different than they were 10 years ago, but I still feel young inside and outside. And I still am very motivated to keep going and especially at this stage.
“I mean, it’s always been the case but, especially now, more or less everything is about grand slams in terms of how I see tennis and how I approach them because, you know, they matter the most.
“So I will definitely try to play my best tennis and aim to play my best tennis at this event.”
Djokovic admitted his Wimbledon win, after a historic tie-break at 12-12 in the deciding set, was one of his most memorable matches.
“It’s in the top two matches I have ever played,” he added. “The other match is the one against Nadal in the final of the (2012) Australian Open which went almost for six hours.
“So those two matches really are very special and take a special place in my career and my mind as well.
“I still have flashes from the Australian match, many years after. And of course I would wish to remember the Wimbledon final against Roger this year for many years to come.”
Former Wimbledon runner-up Kevin Anderson has withdrawn from the US Open with a knee injury.
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Serena Williams will start her bid for a seventh US Open singles crown against familiar foe Maria Sharapova.
Williams’ match-up with Sharapova is the pick of the women’s first-round draw, which sees British number one Johanna Konta start out against Russia’s Daria Kasatkina.
Sharapova upset Williams to win the Wimbledon title in 2004, a result which prevented the American from claiming a third consecutive title at SW19.
But 23-times Grand Slam singles champion Williams holds a convincing 19-2 lead in their head-to-head battles, with the 2012 Olympics, 2013 French Open and 2015 Australian Open among her final victories over the Russian.
Konta, the number 16 seed, has an awkward first-round assignment as Kasatkina has won their two previous meetings in Moscow and Dubai.
Number one seed Naomi Osaka starts the defence of her title against Russia’s Anna Blinkova.
Wimbledon sensation Cori Gauff has a fascinating first-round tie with Anastasia Potapova.
The 15-year-old Gauff reached the fourth round at SW19 and received a wild card to play at Flushing Meadows.
Russian Potapova is a former junior number one, as well as the 2016 Wimbledon girls’ singles champion.
Britain has three players in the men’s draw – Kyle Edmund, Dan Evans and Cameron Norrie.
British number one Kyle Edmund, the 30th seed, meets Spanish veteran Pablo Andujar in the first round, while Evans comes up against Adrian Mannarino of France.
Norrie has been drawn against a qualifier ahead of what could be a second-round meeting with 15th seed David Goffin.
Three-time champion Novak Djokovic, the number one seed, begins the defence of his title against Spain’s Roberto Carballes Baena.
Djokovic is in the same half of the draw as five-time champion Roger Federer, who will play a qualifier in the first round, and is projected to meet the dangerous Russian Daniil Medvedev in the quarter-final.
Second seed Rafael Nadal has a tricky opening against John Millman, the Australian who beat Federer in four sets at the US Open 12 months ago.
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Andy Murray has confirmed he will not be competing in either singles or doubles tennis at this month’s US Open.
The former world number one, who will face brother Jamie in the men’s doubles quarter-finals at the Cincinnati Masters, had been scheduled to play doubles in New York.
But he has opted to focus on singles competition elsewhere as he bids to step up his return from the career-saving hip surgery he underwent in January.
“I’m not going to play doubles at the US Open,” Murray told BBC Sport.
“My goal is to get back playing at the level that I want to on the singles court, and I’ve decided that I need to focus all my energies on that right now.
“The US Open, doubles and mixed, can be another couple of weeks that you are slowing things down.”
Murray and partner Feliciano Lopez beat Ryan Harrison and Jack Sock 2-6 6-3 10-7 to reach the last eight in Cincinnati after Jamie and Neal Skupski overcame French pair Nicolas Mahut and Pierre-Hugues Herbert 6-3 6-3.
Murray will play in next week’s ATP event in Winston-Salem after being given a wild card and will then consider entering a tournament on the Challenger Tour during the US Open, which starts on August 26.
In the Cincinnati singles, Roger Federer suffered a shock loss to Russian qualifier Andrey Rublev in the third round.
Rublev, the world number 70, broke Federer three times as he powered to a stunning 6-3 6-4 win in 62 minutes.
The defeat was a blow to 20-time major champion Federer’s US Open preparations.
Rublev will now play compatriot Daniil Medvedev in the quarter-finals after the biggest win of his career.
World number three Federer said on www.atp.com: “He was super clean – defence, offence, serving well. Didn’t give me anything. He was everywhere.
“So it was tough for me, but an excellent match by him. I was impressed.”
Meanwhile, Novak Djokovic beat Pablo Carreno Busta in straight sets, 6-3 6-4. Djokovic will next play Lucas Pouille in the quarter-final.