McGregor defeated Dos Anjos’ compatriot Jose Aldo in spectacular fashion to win the featherweight title at UFC 194.
He will now look to become the first fighter in history to hold UFC world titles in two different weight classes simultaneously, when he challenges the reigning Brazilian lightweight champion.
Also on the card, women’s bantamweight champion Holly Holm puts her world title on the line for the first time against Miesha Tate in the co-main event.
In her first fight since shocking the world and knocking out Ronda Rousey in November, Holm will defend her crown against an opponent who is unbeaten in over two years.
Heavyweight hitters Gabriel Gonzaga (17-10) and Russian star Ruslan Magomedov (14-1) will collide at the Zagreb Arena as the Brazilian legend looks to put a stop to the Russian’s nine fight win streak.
Additionally involved in this historic event will be local MMA superstar Igor Pokajac (25-12) who will make his return to the Octagon as he faces Poland’s Jan Blachowicz (18-5) in a light heavyweight battle. Pokrajac is coming off three first round finishes and will be looking to make a statement against Blachowicz in his hometown.
“I’m honoured to fight in Zagreb in front of my countrymen,” commented Pokrajac. “The arena will be packed and knowing the Croatian audience it will be loud! I know I will bring a good fight for the fans and put on a show.”